These Are the 8 Best Methylated Multivitamins to Help Boost Your Health

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In general, multivitamins can help fill any nutritional gaps that you might have in your diet, but there are a lot of things to consider when choosing a multivitamin: ingredients, dosage, third-party testing — but also, the form of those vitamins. Enter: methylated multivitamins.

Methylated multivitamins are supplements that contain different forms of vitamins, usually different forms of vitamin B12 (cobalamin) and B9 (folate). Methylcobalamin is a common methylated form of B12, and L-methylfolate is a common methylated form of B9. Methylation is a chemical process that may make these B vitamins more bioavailable, which means they are more easily absorbed and put to use by your body.

 “B12 and folate are unique vitamins because they need to undergo methylation to be effectively utilized by the body,” explains Kate Brock, LDN, owner of Kate Brock Nutrition. “If this process is impaired [within the body], methylated forms of these nutrients become essential for proper absorption,” she says, noting that research in this area is still evolving.
Methylated vitamins, more specifically methylated folate, may be important for people who have a specific gene variation called “MTHFR,” which reduces their ability to convert folate to its active methylated forms — although research is not conclusive on the benefits of methylated folate supplementation in this population.

 Still, Rachel Naar, RD, owner of Rachel Naar Nutrition in Hoboken, New Jersey, says that she recommends this type of multivitamin to many of her clients. “Many with the MTHFR mutation are unaware they have it,” she says, adding that “people with absorption issues (inflammatory bowel disease, celiac disease, pancreatic insufficiency, low stomach acid), older adults, vegans/vegetarians, and pregnant people might also want to consider taking methylated vitamins.”

If it’s been recommended that you take this type of multivitamin, we’re here to help. We consulted RDs, reviewed the research, and evaluated over 20 different popular methylated multivitamins on the market. Here are the eight we recommend.

When to Consult Your Doctor

Everyday Health recommends that you consult a healthcare provider before adding any new supplement to your routine. While most methylated multivitamins are safe, you may not need a multivitamin if you’re getting enough nutrients from your diet, and you may not need a methylated multivitamin if you’ve been tested and don’t have the gene variant that prevents you from absorbing unmethylated vitamins. Additionally, some multivitamins may contain added herbs or higher levels of certain vitamins or minerals that can interfere with medications.

Best Budget

Life Extension Two-Per-Day

$18 at Amazon

Pros

  • Most affordable on our list
  • Contains added antioxidants
  • Third-party tested
  • Non-GMO

Cons

  • Two tablet serving size
  • Doesn’t contain iron
  • Form: Tablet
  • Serving size: Two tablets
  • Third-party tested: Yes
  • Dietary considerations: Non-GMO, gluten-free
Life Extension’s Two-Per-Day Multivitamin is hands down the best bang for your buck methylated multivitamin. This supplement meets the recommended dietary allowance (RDA) of methylated vitamin B12 (methylcobalamin) and methylated B9 (L-5-methyltetrahydrofolate), as well as a methylated form of selenium, an essential mineral (included in most multivitamins) that’s important for reproductive, thyroid, and cellular health.

 We love that these multivitamins are gluten-free, made without genetically modified organisms (non-GMO), and are certified by ConsumerLab (an independent third-party company).
This multivitamin contains way more than just vitamins and minerals — it also packs a potent punch of antioxidants such as quercetin, lycopene, and alpha-lipoic acid, which all support cellular health.

 Though all three of these antioxidants are found in many fruits and vegetables, Life Extension adds them to their formulation — an addition that is not always made to multivitamins, let alone vitamins that are budget-friendly.

Best One-a-Day

Pure Encapsulations O.N.E. Multivitamin

$86 at Walmart
$70.80Now -21% Off

Pros

  • One capsule daily
  • Contains added antioxidants
  • Free from common allergens (wheat, soy, dairy, eggs, tree nuts, peanuts)
  • Non-GMO
  • Third-party tested

Cons

  • Does not contain iron
  • Distinct taste may not appeal to all
  • Form: Capsule
  • Serving size: One capsule
  • Third-party tested: Yes
  • Dietary considerations: Free from common allergens (wheat, soy, dairy, eggs, tree nuts, peanuts, sesame seeds), non-GMO, gluten-free
Sticking to a supplement routine can be a challenge, especially if you are already taking other medications on a daily basis. Pure Encapsulations O.N.E. Multivitamin makes it easy to add a multivitamin to your routine, though, because all you have to do is take one capsule daily. Pure Encapsulations is one of our favorite supplement brands because they’re stringent about purity and quality and their products are third-party tested by ConsumerLab. The O.N.E. Multivitamin is free of gluten, GMOs, and unnecessary binders and fillers. In addition to containing methylated forms of vitamins B12 and B9, this multivitamin also contains several antioxidants including coenzyme Q10, which has been shown to be beneficial for heart health, fertility, and muscle health.

This multivitamin doesn’t contain iron, so if you’re deficient, you’ll need to add an iron supplement. Note, however, that it is common for multivitamins to leave iron out of their formulation, since it can sometimes cause unwanted side effects like constipation. Additionally, most people get enough iron from their diet, so you shouldn’t supplement unless you have a known deficiency.

Best Gummy

Nordic Naturals Zero Sugar Multivitamin Gummies

$23.49 at Amazon
$27.95Now 16% Off

Pros

  • Gummy format for those who don’t like pills
  • RDA of methylated B12
  • Sugar-free
  • Non-GMO
  • Third-party tested

Cons

  • Does not contain methylated B9
  • Contains fewer nutrients than other products on our list
  • Stevia may cause bloating or nausea in some people
  • Form: Gummy
  • Serving size: Two gummies
  • Third-party tested: Yes
  • Dietary considerations: Vegetarian, non-GMO

Swallowing pills isn’t for everyone. If a gummy vitamin is more your speed, Nordic Naturals Zero Sugar Multivitamin Gummies is our top pick. This multivitamin doesn’t have as many vitamins and minerals as some of the others on our list, but it does contain the recommended RDA of methylated vitamin B12. Also, while it does contain folic acid, it’s not the methylated form. Because this vitamin contains fewer vitamins and minerals than others on this list, it could be a good option for those with very specific vitamin and nutrient needs.

Nordic Naturals prides itself on purity, integrity, and transparency, so every one of its products is tested to verify potency, purity, and freshness by certified laboratories (although the laboratories are not listed on their website). Customers can enter the lot number of their product on the Nordic Naturals website to see the certificate of analysis. Also, Nordic Naturals understands that no one wants their multivitamin with a side of sugar, so they sweeten their gummies with stevia. It’s important to note that although stevia is a natural noncaloric sweetener, it can have some unwanted side effects, such as bloating or nausea.

Best for Vegans

Metagenics Daily Wellbeing PhytoMulti Multivitamin With Iron

$43.50 at Amazon
$47.85Now 9% Off

Pros

  • Made with plant-based ingredients
  • Non-GMO
  • Contains wide variety of vitamins, minerals, phytonutrients

Cons

  • Large tablets may not be easy to swallow
  • Form: Tablet
  • Serving size: Two tablets
  • Third-party tested: Yes
  • Dietary considerations: Vegan, gluten-free, non-GMO
Vegan diets can be wonderful for a person’s health, as well as the health of the planet, but if they’re not followed with intention and careful planning, they can lead to vitamin and mineral deficiencies. Two of the biggest deficiencies in vegan diets are iron and vitamin B12, since these two nutrients are mostly found in meat and seafood.

 Metagenics Daily Wellbeing PhytoMulti Multivitamin With Iron is my go-to pick for vegan clients. One serving contains 18 milligrams of iron, which meets the recommended daily intake for adult men and women who are not pregnant or lactating.

This supplement contains high doses of methylated vitamins B12 and B9 (200 micrograms and 1,360 micrograms of dietary folate equivalents, respectively). These doses are well over the RDA for vitamin B12 and B9 (2.4 micrograms for adults and 400 micrograms for women who are not pregnant or lactating, respectively).

In addition to the many vitamins and minerals this supplement includes, it also contains phytonutrients. Phytonutrients are chemical compounds produced by plants that have a variety of positive roles in our health, such as keeping cells healthy and decreasing inflammation.

Best for Women

Rainbow Light High Potency Women’s One Daily Multivitamin

$11.45 at Amazon
$14.44Now 21% Off

Pros

  • Contains vitamins and minerals for women of childbearing age
  • Contains ingredients for digestive health
  • Third-party tested
  • One tablet serving size

Cons

  • Doesn’t contain methylated B9
  • Not everyone needs ashwagandha, probiotics, or digestive enzymes 
  • Form: Tablet
  • Serving size: One tablet
  • Third-party tested: Yes
  • Dietary considerations: Gluten-free, non-GMO, vegetarian, free from common allergens
Supplementation should be personalized for every individual, but for women of childbearing age, taking a multivitamin that contains a variety of vitamins and minerals, especially iron, calcium, vitamin D, vitamin B12, and folate, can be beneficial for supporting energy levels, bone health, and hormone health.

 Rainbow Light High Potency Women’s One Daily Multivitamin covers all of those nutrient bases and also includes a blend of superfoods and ingredients to support digestive health, such as ginger, probiotics, and two vegan digestive enzymes (papain and bromelain).

This multivitamin doesn’t skimp on quality — it’s free of common allergens, Non-GMO Project verified, and tested by ConsumerLab. This supplement contains methylated vitamin B12 (10 micrograms) but not the methylated form of B9. In addition to including vitamins, minerals, and ingredients for gut health, Rainbow Light includes the adaptogen ashwagandha. Though many may benefit from ashwagandha’s ability to help people handle stress, some may experience unwanted side effects, such as upset stomach or drowsiness.

Best for Men

Pure Encapsulations Men’s Nutrients

$72.40 at Amazon

Pros

  • Contains ingredients for prostate health
  • Capsules may be easier to swallow for some
  • Non-GMO

Cons

  • Three capsule serving size
  • “Enduraboost Blend” may not benefit all 
  • Form: Capsule
  • Serving size: Three capsules
  • Third-party tested: Yes
  • Dietary considerations: Gluten-free, non-GMO, dairy-free, soy-free
Unlike women of childbearing age, men don’t have specific vitamin and mineral requirements recommended by the National Institutes of Health’s Office of Dietary Supplements.

 In general, a broad-spectrum multivitamin that contains a variety of essential vitamins and minerals could still be supportive of men’s health, if the person is dietarily deficient.
Multivitamins that our team would recommend to men are products that have added antioxidants known to support prostate and heart health. Pure Encapsulations Men’s Nutrients is a multivitamin that contains methylated forms of vitamins B12 and B9, as well as the full profile of other vitamins (vitamins C, A, D, E, K, and B vitamins), and a wide variety of minerals. This supplement is uniquely designed for men: It includes 500 milligrams of lycopene, a phytonutrient found in tomatoes that has been shown to have protective effects against prostate cancer.

 This multivitamin also includes a “cardio polyphenol complex” made up of grape and pomegranate, two fruits with high polyphenol activity that may have positive effects on heart health.

 This supplement also contains two ingredients that may help support erectile function and fertility: maca and astragalus. Though these ingredients are generally safe, it is important to consult your doctor if you are currently taking other prescription medications.

Best Prenatal

Perelel Prenatal Packs

$58.26 at Amazon

Pros

  • Supplement packs based on pregnancy stage
  • Gluten-free, soy-free, dairy-free, non-GMO
  • Third-party tested
  • HSA-eligible, FSA-eligible
  • cGMP certified

Cons

  • Priciest on our list
  • Multiple softgels and capsules per serving
  • Form: Softgels and capsules
  • Serving size: One pack
  • Third-party tested: Yes
  • Dietary considerations: Gluten-free, dairy-free, soy-free, non-GMO
Perelel is a unique supplement company that offers individual packets of supplements they have created with the intention of supporting each stage of pregnancy. Perelel’s mission is to support the entire pregnancy process, from preconception through postpartum. For example, their Conception Support Pack includes CoQ10 for egg health and the 1st Trimester Prenatal Pack includes ginger to help with nausea.

As a woman progresses through her pregnancy, the other supplement packs are tailored to the unique needs of whichever trimester she’s in. Every pack contains ingredients in their most bioavailable form — for example, cholecalciferol is included (vitamin D3) instead of ergocalciferol vitamin D2, including methylated vitamin B12 and folate (amounts vary to meet the RDA of each pregnancy stage). Each pack includes five pills, both softgels and capsules. Perelel’s products are third-party tested (labs are not disclosed on their website) and made in a certified facility that uses Current Good Manufacturing Practices (cGMP). These supplements are a bit pricier than other prenatal multivitamins, but they’re eligible to buy with a health savings account (HSA) or flexible spending account (FSA), which can make them a bit more accessible.

Best Subscription

Ritual Essential for Women Multivitamin 18+

$36.99 at Amazon

Pros

  • Transparent ingredient sourcing
  • Third-party tested
  • Non-GMO
  • Other multivitamin subscriptions available for both men and women

Cons

  • Serving size is two capsules
  • Contains fewer nutrients than other products on our list
  • Form: Capsule
  • Serving size: Two capsules
  • Third-party tested: Yes
  • Dietary considerations: Vegan, gluten-free, free from major allergens

There are many subscription options available when it comes to supplements, but Ritual is our favorite because of the quality and the variety of products offered. Ritual makes multivitamins with methylated ingredients (vitamin B12 and B9) for women over 18, women over 50, men over 18, and male and female teens.

Ritual Essential for Women Multivitamin 18+ features nine ingredients: methylated B9 and B12, iron, vitamin D3, vitamin K2, omega-3 DHA, boron, vitamin E, and magnesium — all of which can be traced back to their supplier and final place of manufacturing. Ritual takes a “less is more approach” when creating their supplements. This multivitamin contains fewer ingredients than other products on this list, and instead focuses on where certain groups of individuals more commonly have gaps in their diet. “Too much of anything isn’t a good thing,” says Isabel Smith, RD, owner of Isabel Smith Nutrition and Lifestyle. We love that this supplement contains methylated vitamin B12 and B9, plus magnesium, a mineral that supports methylation.

According to their website, Ritual uses third-party labs to test for heavy metals and allergens, and their products are Non-GMO Project verified, although they don’t list the labs they utilize. Compared to other subscription multivitamins, Ritual is more affordable at $33 per month.

Comparison Table

Best for
Highlights
Budget
  • Tablet
  • Serving size: 2 tablets
  • Third-party tested
  • Gluten-free, non-GMO
One-a-day
  • Capsule
  • Serving size: 1 capsule
  • Third-party tested
  • Gluten-free, non-GMO
Gummy
  • Gummy
  • Serving size: 2 gummies
  • Third-party tested
  • Vegetarian, non-GMO
Vegan
  • Tablet
  • Serving size: 2 tablets
  • Third-party tested
  • Vegan, gluten-free, non-GMO
Women
  • Tablet
  • Serving size: 1 tablet
  • Third-party tested
  • Gluten-free, vegetarian, non-GMO, free of common allergens
Men
  • Capsule
  • Serving size: 2 capsules
  • Third-party tested
  • Gluten-free, non-GMO, dairy-free, soy-free
Prenatal
  • Mixed (softgels and capsules)
  • Serving size: 1 pack
  • Third-party tested
  • Gluten-free, dairy-free, soy-free, non-GMO
Subscription
  • Capsule
  • Serving size: 2 capsules
  • Third-party tested
  • Vegan, gluten-free, free of major allergens

How We Chose the Best Methylated Multivitamins

When seeking out the best supplements in any category, I base my product picks on whether I would recommend them to a client or loved one. As a practicing registered dietitian, I’ve developed a keen eye for products and use evidence-based practice to help guide what supplements I choose. First, I look to see what products have been vetted by third-party labs. Then I look for products that are free of common allergens and unnecessary additives. I also look for products that contain minimal herbs and botanical ingredients, as these are sometimes not well tolerated by certain individuals. Over 20 products were considered for this article.

What to Look for When Buying Methylated Multivitamins

Choosing a multivitamin can be overwhelming, but there are things to consider that can make you a more discerning shopper. First, you should only buy supplements if you need them. For example, if you aren’t iron-deficient, it may not be beneficial (and might even be harmful) to take a multivitamin that includes iron. Second, as noted above, you may not even need to take a methylated multivitamin; this is something to discuss with your doctor or healthcare provider.

If you do need to supplement with any methylated vitamins, these are the things to look for:

  • Third-party testing: Check to see that the supplement has been third-party tested for purity and potency.
  • Added ingredients: Make sure the supplement doesn’t contain any ingredients that you may be allergic to or have sensitivities to or that may interfere with any medications you take.
  • Added sugar: Avoid supplements that contain added sugars.
  • Serving size: If taking multiple pills is difficult, look for a one-a-day multivitamin.

What to Avoid When Buying Methylated Multivitamins

When purchasing any supplement, it’s important to avoid products that sound too good to be true. If a multivitamin promises to “cure” health issues or makes other extravagant claims, you should probably leave it on the shelf. You should also avoid products that contain very low or very high doses of vitamins and minerals (you can look at the percent daily value on the ingredient list as a guide). You can also use the National Institutes of Health’s Dietary Reference Intakes to help you choose the best multivitamin for your needs.

Do Women of Childbearing Age Need Methylated Folate?

It is important to note that although some experts have recommended methylated folate for women who may become pregnant, the Centers for Disease Control and Prevention has weighed in on this and has concluded that 400 micrograms per day of folic acid, not 5-MTHF, is adequate for women who may become pregnant, even if they have a MTHFR mutation. People with an MTHFR gene variant can process all types of folate, including folic acid. Getting 400 micrograms of folic acid daily can help prevent neural tube defects.

FAQs

Who should take methylated multivitamins?

More research is needed to more definitively determine who may benefit more from a methylated multivitamin than a conventional one. For now, the individuals who may benefit more from methylated multivitamins, specifically methylated folate, are those who have variations in specific genes that may affect their ability to process nonmethylated vitamins. One test that is used to determine this is MTHFR mutation testing, though medical and genetic experts do not generally recommend this testing.

Methylated vitamins have the same potential side effects as regular multivitamins. You may feel nauseous if you take methylated vitamins on an empty stomach. Some methylated multivitamins may also contain higher amounts of a vitamin or mineral than you need and may lead to serious health issues. That’s why it’s always important to consult your doctor or healthcare provider before taking a new supplement.

Why Trust Everyday Health

We independently investigate and recommend products and services we believe will enrich the lives of our readers and meet their specific needs. You can trust our reviews because we do the legwork for you. Read more about why you can trust us.

Sydney Greene, MS, RDN

Author

Sydney Greene is a freelance writer and a registered dietitian specializing in behavioral health nutrition. She received her bachelor of science in nutrition and dietetics and her master of science in clinical nutrition from New York University.

Sydney began her career in New York City and worked at one of the top private practices in Manhattan while building the nutrition curriculum for a residential treatment center. She then started her own private practice, Greene Health, in 2019, and has since helped hundreds of clients on their path to recovery from eating disorders, substance use disorders, anxiety, depression, and common chronic illnesses. “Healthy” is far from cookie-cutter and there’s no formula, so Sydney approaches nutrition in a realistic, down-to-earth, grounded, and highly personalized way with her clients.

Sydney currently lives in Boulder, Colrado, with her dog, Charlie, and her wife. When she is not working with clients, you can find her hiking in the backcountry or spending time with friends.

Justin Laube, MD

Justin Laube, MD

Medical Reviewer

Justin Laube, MD, is a board-certified integrative and internal medicine physician, a teacher, and a consultant with extensive expertise in integrative health, medical education, and trauma healing.

He graduated with a bachelor's in biology from the University of Wisconsin and a medical degree from the University of Minnesota Medical School. During medical school, he completed a graduate certificate in integrative therapies and healing practices through the Earl E. Bakken Center for Spirituality & Healing. He completed his three-year residency training in internal medicine at the University of California in Los Angeles on the primary care track and a two-year fellowship in integrative East-West primary care at the UCLA Health Center for East-West Medicine.

He is currently taking a multiyear personal and professional sabbatical to explore the relationship between childhood trauma, disease, and the processes of healing. He is developing a clinical practice for patients with complex trauma, as well as for others going through significant life transitions. He is working on a book distilling the insights from his sabbatical, teaching, and leading retreats on trauma, integrative health, mindfulness, and well-being for health professionals, students, and the community.

Previously, Dr. Laube was an assistant clinical professor at the UCLA Health Center for East-West Medicine and the David Geffen School of Medicine at UCLA, where he provided primary care and integrative East-West medical consultations. As part of the faculty, he completed a medical education fellowship and received a certificate in innovation in curriculum design and evaluation. He was the fellowship director at the Center for East-West Medicine and led courses for physician fellows, residents, and medical students.

EDITORIAL SOURCES
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