These Are the 8 Best Methylated Multivitamins to Help Boost Your Health
In general, multivitamins can help fill any nutritional gaps that you might have in your diet, but there are a lot of things to consider when choosing a multivitamin: ingredients, dosage, third-party testing — but also, the form of those vitamins. Enter: methylated multivitamins.
If it’s been recommended that you take this type of multivitamin, we’re here to help. We consulted RDs, reviewed the research, and evaluated over 20 different popular methylated multivitamins on the market. Here are the eight we recommend.
Our Top Picks for Methylated Vitamins
- Best budget: Life Extension Two-Per-Day Multivitamin
- Best one-a-day: Pure Encapsulations O.N.E. Multivitamin
- Best gummy: Nordic Naturals Zero Sugar Multivitamin Gummies
- Best for vegans: Metagenics Daily Wellbeing PhytoMulti Multivitamin With Iron
- Best for women: Rainbow Light High Potency Women’s One Daily Multivitamin
- Best for men: Pure Encapsulations Men’s Nutrients
- Best prenatal: Perelel Prenatal Packs
- Best subscription: Ritual Essential for Women Multivitamin 18+
When to Consult Your Doctor

Best Budget
Life Extension Two-Per-Day
Pros
- Most affordable on our list
- Contains added antioxidants
- Third-party tested
- Non-GMO
Cons
- Two tablet serving size
- Doesn’t contain iron
- Form: Tablet
- Serving size: Two tablets
- Third-party tested: Yes
- Dietary considerations: Non-GMO, gluten-free

Best One-a-Day
Pure Encapsulations O.N.E. Multivitamin
Pros
- One capsule daily
- Contains added antioxidants
- Free from common allergens (wheat, soy, dairy, eggs, tree nuts, peanuts)
- Non-GMO
- Third-party tested
Cons
- Does not contain iron
- Distinct taste may not appeal to all
- Form: Capsule
- Serving size: One capsule
- Third-party tested: Yes
- Dietary considerations: Free from common allergens (wheat, soy, dairy, eggs, tree nuts, peanuts, sesame seeds), non-GMO, gluten-free
This multivitamin doesn’t contain iron, so if you’re deficient, you’ll need to add an iron supplement. Note, however, that it is common for multivitamins to leave iron out of their formulation, since it can sometimes cause unwanted side effects like constipation. Additionally, most people get enough iron from their diet, so you shouldn’t supplement unless you have a known deficiency.

Best Gummy
Nordic Naturals Zero Sugar Multivitamin Gummies
Pros
- Gummy format for those who don’t like pills
- RDA of methylated B12
- Sugar-free
- Non-GMO
- Third-party tested
Cons
- Does not contain methylated B9
- Contains fewer nutrients than other products on our list
- Stevia may cause bloating or nausea in some people
- Form: Gummy
- Serving size: Two gummies
- Third-party tested: Yes
- Dietary considerations: Vegetarian, non-GMO
Swallowing pills isn’t for everyone. If a gummy vitamin is more your speed, Nordic Naturals Zero Sugar Multivitamin Gummies is our top pick. This multivitamin doesn’t have as many vitamins and minerals as some of the others on our list, but it does contain the recommended RDA of methylated vitamin B12. Also, while it does contain folic acid, it’s not the methylated form. Because this vitamin contains fewer vitamins and minerals than others on this list, it could be a good option for those with very specific vitamin and nutrient needs.

Best for Vegans
Metagenics Daily Wellbeing PhytoMulti Multivitamin With Iron
Pros
- Made with plant-based ingredients
- Non-GMO
- Contains wide variety of vitamins, minerals, phytonutrients
Cons
- Large tablets may not be easy to swallow
- Form: Tablet
- Serving size: Two tablets
- Third-party tested: Yes
- Dietary considerations: Vegan, gluten-free, non-GMO

Best for Women
Rainbow Light High Potency Women’s One Daily Multivitamin
Pros
- Contains vitamins and minerals for women of childbearing age
- Contains ingredients for digestive health
- Third-party tested
- One tablet serving size
Cons
- Doesn’t contain methylated B9
- Not everyone needs ashwagandha, probiotics, or digestive enzymes
- Form: Tablet
- Serving size: One tablet
- Third-party tested: Yes
- Dietary considerations: Gluten-free, non-GMO, vegetarian, free from common allergens

Best for Men
Pure Encapsulations Men’s Nutrients
Pros
- Contains ingredients for prostate health
- Capsules may be easier to swallow for some
- Non-GMO
Cons
- Three capsule serving size
- “Enduraboost Blend” may not benefit all
- Form: Capsule
- Serving size: Three capsules
- Third-party tested: Yes
- Dietary considerations: Gluten-free, non-GMO, dairy-free, soy-free

Best Prenatal
Perelel Prenatal Packs
Pros
- Supplement packs based on pregnancy stage
- Gluten-free, soy-free, dairy-free, non-GMO
- Third-party tested
- HSA-eligible, FSA-eligible
- cGMP certified
Cons
- Priciest on our list
- Multiple softgels and capsules per serving
- Form: Softgels and capsules
- Serving size: One pack
- Third-party tested: Yes
- Dietary considerations: Gluten-free, dairy-free, soy-free, non-GMO
As a woman progresses through her pregnancy, the other supplement packs are tailored to the unique needs of whichever trimester she’s in. Every pack contains ingredients in their most bioavailable form — for example, cholecalciferol is included (vitamin D3) instead of ergocalciferol vitamin D2, including methylated vitamin B12 and folate (amounts vary to meet the RDA of each pregnancy stage). Each pack includes five pills, both softgels and capsules. Perelel’s products are third-party tested (labs are not disclosed on their website) and made in a certified facility that uses Current Good Manufacturing Practices (cGMP). These supplements are a bit pricier than other prenatal multivitamins, but they’re eligible to buy with a health savings account (HSA) or flexible spending account (FSA), which can make them a bit more accessible.

Best Subscription
Ritual Essential for Women Multivitamin 18+
Pros
- Transparent ingredient sourcing
- Third-party tested
- Non-GMO
- Other multivitamin subscriptions available for both men and women
Cons
- Serving size is two capsules
- Contains fewer nutrients than other products on our list
- Form: Capsule
- Serving size: Two capsules
- Third-party tested: Yes
- Dietary considerations: Vegan, gluten-free, free from major allergens
There are many subscription options available when it comes to supplements, but Ritual is our favorite because of the quality and the variety of products offered. Ritual makes multivitamins with methylated ingredients (vitamin B12 and B9) for women over 18, women over 50, men over 18, and male and female teens.
Ritual Essential for Women Multivitamin 18+ features nine ingredients: methylated B9 and B12, iron, vitamin D3, vitamin K2, omega-3 DHA, boron, vitamin E, and magnesium — all of which can be traced back to their supplier and final place of manufacturing. Ritual takes a “less is more approach” when creating their supplements. This multivitamin contains fewer ingredients than other products on this list, and instead focuses on where certain groups of individuals more commonly have gaps in their diet. “Too much of anything isn’t a good thing,” says Isabel Smith, RD, owner of Isabel Smith Nutrition and Lifestyle. We love that this supplement contains methylated vitamin B12 and B9, plus magnesium, a mineral that supports methylation.
According to their website, Ritual uses third-party labs to test for heavy metals and allergens, and their products are Non-GMO Project verified, although they don’t list the labs they utilize. Compared to other subscription multivitamins, Ritual is more affordable at $33 per month.
Comparison Table
- Tablet
- Serving size: 2 tablets
- Third-party tested
- Gluten-free, non-GMO
- Capsule
- Serving size: 1 capsule
- Third-party tested
- Gluten-free, non-GMO
- Gummy
- Serving size: 2 gummies
- Third-party tested
- Vegetarian, non-GMO
- Tablet
- Serving size: 2 tablets
- Third-party tested
- Vegan, gluten-free, non-GMO
- Tablet
- Serving size: 1 tablet
- Third-party tested
- Gluten-free, vegetarian, non-GMO, free of common allergens
- Capsule
- Serving size: 2 capsules
- Third-party tested
- Gluten-free, non-GMO, dairy-free, soy-free
- Mixed (softgels and capsules)
- Serving size: 1 pack
- Third-party tested
- Gluten-free, dairy-free, soy-free, non-GMO
- Capsule
- Serving size: 2 capsules
- Third-party tested
- Vegan, gluten-free, free of major allergens
How We Chose the Best Methylated Multivitamins
What to Look for When Buying Methylated Multivitamins
Choosing a multivitamin can be overwhelming, but there are things to consider that can make you a more discerning shopper. First, you should only buy supplements if you need them. For example, if you aren’t iron-deficient, it may not be beneficial (and might even be harmful) to take a multivitamin that includes iron. Second, as noted above, you may not even need to take a methylated multivitamin; this is something to discuss with your doctor or healthcare provider.
If you do need to supplement with any methylated vitamins, these are the things to look for:
- Third-party testing: Check to see that the supplement has been third-party tested for purity and potency.
- Added ingredients: Make sure the supplement doesn’t contain any ingredients that you may be allergic to or have sensitivities to or that may interfere with any medications you take.
- Added sugar: Avoid supplements that contain added sugars.
- Serving size: If taking multiple pills is difficult, look for a one-a-day multivitamin.
What to Avoid When Buying Methylated Multivitamins
When purchasing any supplement, it’s important to avoid products that sound too good to be true. If a multivitamin promises to “cure” health issues or makes other extravagant claims, you should probably leave it on the shelf. You should also avoid products that contain very low or very high doses of vitamins and minerals (you can look at the percent daily value on the ingredient list as a guide). You can also use the National Institutes of Health’s Dietary Reference Intakes to help you choose the best multivitamin for your needs.
Do Women of Childbearing Age Need Methylated Folate?
FAQs
More research is needed to more definitively determine who may benefit more from a methylated multivitamin than a conventional one. For now, the individuals who may benefit more from methylated multivitamins, specifically methylated folate, are those who have variations in specific genes that may affect their ability to process nonmethylated vitamins. One test that is used to determine this is MTHFR mutation testing, though medical and genetic experts do not generally recommend this testing.
Why Trust Everyday Health

Sydney Greene, MS, RDN
Author
Sydney Greene is a freelance writer and a registered dietitian specializing in behavioral health nutrition. She received her bachelor of science in nutrition and dietetics and her master of science in clinical nutrition from New York University.
Sydney began her career in New York City and worked at one of the top private practices in Manhattan while building the nutrition curriculum for a residential treatment center. She then started her own private practice, Greene Health, in 2019, and has since helped hundreds of clients on their path to recovery from eating disorders, substance use disorders, anxiety, depression, and common chronic illnesses. “Healthy” is far from cookie-cutter and there’s no formula, so Sydney approaches nutrition in a realistic, down-to-earth, grounded, and highly personalized way with her clients.
Sydney currently lives in Boulder, Colrado, with her dog, Charlie, and her wife. When she is not working with clients, you can find her hiking in the backcountry or spending time with friends.

Justin Laube, MD
Medical Reviewer
Justin Laube, MD, is a board-certified integrative and internal medicine physician, a teacher, and a consultant with extensive expertise in integrative health, medical education, and trauma healing.
He graduated with a bachelor's in biology from the University of Wisconsin and a medical degree from the University of Minnesota Medical School. During medical school, he completed a graduate certificate in integrative therapies and healing practices through the Earl E. Bakken Center for Spirituality & Healing. He completed his three-year residency training in internal medicine at the University of California in Los Angeles on the primary care track and a two-year fellowship in integrative East-West primary care at the UCLA Health Center for East-West Medicine.
He is currently taking a multiyear personal and professional sabbatical to explore the relationship between childhood trauma, disease, and the processes of healing. He is developing a clinical practice for patients with complex trauma, as well as for others going through significant life transitions. He is working on a book distilling the insights from his sabbatical, teaching, and leading retreats on trauma, integrative health, mindfulness, and well-being for health professionals, students, and the community.
Previously, Dr. Laube was an assistant clinical professor at the UCLA Health Center for East-West Medicine and the David Geffen School of Medicine at UCLA, where he provided primary care and integrative East-West medical consultations. As part of the faculty, he completed a medical education fellowship and received a certificate in innovation in curriculum design and evaluation. He was the fellowship director at the Center for East-West Medicine and led courses for physician fellows, residents, and medical students.
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