What Is Diabetic Gastroparesis?

What Is Diabetic Gastroparesis?
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Diabetic gastroparesis is a potential complication of chronically high blood sugar levels where the stomach muscles don’t contract normally. It slows the speed that food moves from the stomach to the intestine, known as gastric emptying, and it can cause severe gastrointestinal discomfort.

 Diabetic gastroparesis may develop in as many as 10 percent of people with diabetes, and can affect those with both type 1 and type 2 diabetes.

There is no cure, but diabetic gastroparesis can be managed with lifestyle changes and medications. In severe cases, surgery may be recommended.

Signs and Symptoms of Diabetic Gastroparesis

Delayed gastric emptying from diabetic gastroparesis can cause many severe digestive symptoms, including:

  • Vomiting
  • Bloating
  • Abdominal pain
  • Heartburn
  • Loss of appetite or feeling full after eating very little
  • Blood sugar fluctuations
  • Weight loss
Signs and Symptoms of Diabetic Gastroparesis

Causes and Risk Factors for Diabetic Gastroparesis

In people with type 1 or type 2 diabetes, gastroparesis can occur if the vagus nerve, which helps control the digestive system and other essential bodily functions, is damaged by unhealthy blood sugar levels. It typically develops in those who’ve been living with diabetes for at least 5 or 10 years.

“This nerve damage affects the stomach’s natural rhythm of contractions, leading to gastroparesis,” says gastroenterologist Bryan Curtin, MD, the director of the center for neurogastroenterology and GI motility at Mercy Medical Center in Baltimore.

Essentially, the muscles in the wall of the stomach don’t function the way they should, causing a delay in gastric emptying.

According to Michael Cline, DO, the medical director of the gastroparesis clinic at Cleveland Clinic, people with gastroparesis almost always have other complications before developing gastroparesis, including nerve damage in the feet and legs and eye or kidney issues.

Gastroparesis can also be the result of abdominal surgery or viral illness, and certain medicines can make it worse.

How Is Diabetic Gastroparesis Diagnosed?

Your doctor will test you to confirm you have diabetic gastroparesis and rule out other causes of gastrointestinal discomfort. The options include:

  • Upper Gastrointestinal Endoscopy Dr. Cline says this procedure can identify a partial blockage or anatomy problem that prevents the stomach from emptying. An endoscopy involves placing a long, flexible tube with a camera attached into the esophagus, stomach, and duodenum, which is the first part of the small intestine beyond the stomach.
  • Ultrasound This imaging test also identifies blockages or anatomy issues, and it uses high-frequency sound waves to create images of organs and tissues inside the body.
  • Scintigraphy This is the next diagnostic step if no blockages or anatomy problems were discovered. It measures how quickly your stomach empties food into the intestine. You eat a light meal that contains a small amount of radioactive material. Then, a technician uses a specialized camera to scan the radioactive material and process it into images. You will be scanned right after you eat, 30 minutes later, and one, two, and four hours later.

Dietary Changes for Diabetic Gastroparesis

Since this is a digestive condition, it’s essential to pay attention to which foods are recommended and what to avoid. Focus on low-fiber, low-fat, soft, and well-cooked foods. Research shows that spicy, acidic, and fatty foods can make symptoms worse.

It may also be helpful to eat smaller, more frequent meals (four to five per day) that don’t contain much soluble fiber, which can be tough to digest. Grains, beans, and legumes all contain soluble fiber.

If you’re concerned that eating for gastroparesis might be difficult with the dietary restrictions you already follow to manage blood sugar, your healthcare team can help you create a healthy eating plan that will check all the right boxes.

Treatment and Medication Options for Diabetic Gastroparesis

Controlling blood sugar levels through dietary changes like avoiding high-fat, highly acidic or spicy foods, insulin or other glucose-lowering medications, and physical activity is critical for people with diabetic gastroparesis. Beyond those core healthy behaviors, your doctor may prescribe additional treatments to manage symptoms.

Medications

Several types of medication can help the muscles in your stomach function properly, control nausea and vomiting, and reduce pain. Options include:

  • Metoclopramide Metoclopramide increases stomach and intestine contractions and eases symptoms such as nausea, vomiting, heartburn, fullness after meals, and loss of appetite.

     This drug has a high risk for tardive dyskinesia if taken for longer than 12 weeks.
  • Erythromycin This antibiotic helps the stomach muscles contract more to improve gastric emptying.

    The antibiotic azithromycin is sometimes used as an alternative.
  • Antiemetics This class of drugs helps prevent and treat nausea and vomiting. Both prescription and over-the-counter (OTC) antiemetics are available, including dimenhydrinate (Dramamine) and bismuth subsalicylate (Pepto-Bismol).

  • Pain Relievers Your physician may recommend non-narcotic pain relievers for severe abdominal pain.

Medical Procedures and Surgery

If your symptoms don’t improve with medication, your physician may recommend gastric electrical stimulation (GES). This procedure involves placing a small, battery-powered device under the skin in your lower abdomen and attaching wires to the stomach muscles. The device sends mild electrical pulses to the nerves and muscles in the stomach, helping stimulate contractions.

If medications and GES aren’t helpful, you may need surgery. These surgical procedures modify the stomach to make it easier for food to pass to the intestine.

  • Pyloroplasty This procedure relaxes and expands the opening of the pylorus, the muscular valve that releases food from the stomach. 
  • Gastric Bypass Also offered as a weight loss surgery for people with type 2 diabetes who have severe obesity, a gastric bypass removes or closes off part of the stomach and creates a new channel between the stomach and small intestine.

Prevention of Diabetic Gastroparesis

The best way to prevent diabetic gastroparesis is to keep your blood sugar within the target range recommended by your doctor.

The following strategies may be effective ways to do that:

  • Check blood sugar regularly.
  • Take medicines as prescribed.
  • Eat a healthy diet.
  • Exercise regularly.
  • Manage stress.
  • Get enough sleep.
  • Reach or maintain a healthy weight.
  • Avoid tobacco products.
  • See your doctor regularly.

Complications of Diabetic Gastroparesis

Because food lingers in the stomach, it can cause blood sugar levels to fluctuate unpredictably. Delayed gastric emptying can interrupt the release of sugar into your bloodstream, leading to hypoglycemia, also known as low blood sugar, especially if you use insulin before meals. Initial symptoms often include shakiness and a rapid heartbeat, but the condition can become life-threatening if not addressed. When food finally is released from the stomach into the small intestine, it could cause blood sugar to spike. Fluctuating blood sugar levels can make it challenging to control your diabetes, which can make it and your gastroparesis worse.

The symptoms of diabetic gastroparesis, including loss of appetite, nausea, and vomiting, can lead to dehydration and make it difficult to get the calories and nutrients your body needs to function.

Some food may not be digested at all. This food hardens into a bezoar, a solid mass that sits in the stomach and may cause nausea and vomiting, or even prevent other foods from passing into the small intestine.

Related Conditions

Diabetic gastroparesis can increase your risk of other digestive conditions, including:

  • Gastroesophageal Reflux Disease (GERD) GERD is a chronic condition where stomach acid travels into your esophagus and throat, causing irritation and inflammation, a burning chest or stomach pain, nausea, sore throat, and chronic coughing.

     
  • Intestinal Dysmotility High blood sugar from diabetes can damage the nerves that coordinate the movements of the intestines, too. This is known as intestinal dysmotility.

The Takeaway

  • Diabetic gastroparesis is a digestive condition in which food moves too slowly from the stomach to the intestines, causing symptoms like nausea, vomiting, bloating, acid reflux, and abdominal pain.
  • Gastroparesis is a severe complication of diabetes. It develops when the vagus nerve that helps control the digestive system becomes damaged by chronic high blood glucose levels, medications, infections, or abdominal surgery.
  • There is no cure for diabetic gastroparesis, but symptoms can be managed by controlling blood sugar through diet and medications. Those same techniques, including exercise, good sleep, and stress management, can also help prevent the disease.

Common Questions & Answers

What causes gastroparesis?
Gastroparesis happens when the vagus nerve that controls digestion becomes damaged. Chronically high blood sugar, abdominal surgery, gastrointestinal infections, and certain medications can compromise the vagus nerve.
Controlling blood sugar through diet and medications is the first step of treatment. If necessary, your healthcare provider may prescribe medications or suggest surgery to address symptoms and speed up the digestive process.
Opt for fat-free or reduced-fat dairy products, lean meats, cooked fruits and vegetables, and nonalcoholic and uncarbonated beverages. Foods that are spicy, fatty, acidic, and high in fiber tend to worsen digestive symptoms.
No, there currently is no cure for diabetic gastroparesis. For many, symptoms can be successfully managed through medicines, diet, and other forms of treatment.

Resources We Trust

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  2. Li L et al. Prevalence of gastroparesis in diabetic patients: a systematic review and meta-analysis. Scientific Reports. August 28, 2023.
  3. Aswath GS et al. Diabetic Gastroparesis. StatPearls. March 27, 2023.
  4. How Does Gastroparesis Affect People With Diabetes? National Institute of Digestive and Kidney Diseases. October 27, 2021.
  5. Gastroparesis. Mayo Clinic. September 6, 2024.
  6. Gastric Emptying Study. Cleveland Clinic. September 20, 2023.
  7. Young CF et al. Diabetic Gastroparesis: A Review. DiabetesSpectrum. 2020.
  8. Treatment for Gastroparesis. National Institute of Digestive and Kidney Diseases. January 2018.
  9. Metoclopramide (Oral Route). Mayo Clinic. February 1, 2025.
  10. Antiemetic Drugs. Cleveland Clinic. January 22, 2025.
  11. Gastroparesis. Cleveland Clinic. February 12, 2025.
  12. Managing Diabetes. National Institute of Diabetes and Digestive and Kidney Diseases. October 2023.
  13. Hypoglycemia (Low Blood Sugar). Cleveland Clinic. January 31, 2023.
  14. Parkman HP et al. Treatment of Patients With Diabetic Gastroparesis. Gastroenterology & Hepatology. June 2010.
  15. Acid Reflux & GERD. Cleveland Clinic. September 28, 2023.
  16. Pal P et al. Editor’s Pick: Disorders of Gastrointestinal Motility in Diabetes Mellitus: An Unattended Borderline Between Diabetologists and Gastroenterologists. European Medical Journal. November 11, 2021.

Kacy Church, MD

Medical Reviewer
Kacy Church, MD, practices as a clinical endocrinologist with the Palo Alto Medical Foundation in Burlingame, California. She balances both outpatient and inpatient responsibilities, seeing a variety of patients with diabetes, as well as thyroid and pituitary disorders.

Dr. Church always knew that she wanted to pursue endocrinology because the specialty allows for healthy change through patient empowerment. She completed her fellowship in endocrinology, diabetes, and metabolism in 2017 at Stanford University in California.

She loves running, dancing, and watching her sons play sports.
Bedosky-bio

Lauren Bedosky

Author
Lauren Bedosky is an experienced health and fitness writer. She regularly contributes to top websites and publications like Men's Health, Women's Health, MyFitnessPal, SilverSneakers, Runner's World, Experience Life, Prevention, AARP, Blue Cross and Blue Shield, UnitedHealthcare, Livestrong, Fitness, Shape, Family Circle, Healthline, Self, Redbook, and Women's Running.

When she's not writing about health and fitness — her favorite topics being anything related to running and strength training — she's reading up on the latest and greatest news in the field and working on her own health goals.