Hyaluronic Acid: Your Complete Guide to the Hydrating Skin Care Ingredient

Hyaluronic acid, an active ingredient in skin care products, is known for its hydrating abilities. Found in serums, cleansers, moisturizers, and more, hyaluronic acid not only moisturizes the skin, but also minimizes signs of aging, since fine lines and wrinkles are less visible on plump, hydrated skin.
What Is Hyaluronic Acid?
The good news is that topical products that feature hyaluronic acid, whether as part of the ingredients list in a moisturizer or as the star of a serum, can help rebuild those depleted stores, says Bonnie Gasquet, MD, an internal medicine physician at Studio Health Medical Spa in Belle Chasse, Louisiana.
Shari Marchbein, MD, a board-certified dermatologist in private practice in New York City, says, “Hyaluronic acid attracts and binds to water molecules and increases the water content of the skin.” It can absorb more than 1,000 times its weight in water, she adds.
The Benefits of Hyaluronic Acid
The key benefit of hyaluronic acid is hydration and its ability to retain moisture. Dehydrated skin, which occurs when the top layer of skin doesn’t have enough water, appears dry, rough, and flaky, says Dr. Marchbein. Beyond aesthetics, dry skin can be unhealthy.
Gasquet recommends applying products with hyaluronic acid, especially during the winter when the skin tends to be at its driest. But even those who aren’t battling dryness can benefit from adding hyaluronic acid to their skin care routine. Kenneth Rothaus, MD, a board-certified plastic surgeon with Rothaus Plastic Surgery in New York City, says hyaluronic acid is responsible for giving the skin a healthy glow.
Marchbein recommends a hyaluronic-packed moisturizer for people of all ages. “It is never too early to start a good skin care routine,” she says.
3 Types of Hyaluronic Acid and How They Differ
There are three types of hyaluronic acid:
- Hydrolyzed hyaluronic acid is hyaluronic acid that has been broken down into elements small enough to penetrate the skin, Gasquet says. It’s moisturizing, but not the most moisturizing option, so it’s best for people who have oily or combination skin, since these skin types want to avoid over-moisturizing.
- Sodium hyaluronate goes deeper into the skin and delivers even better results, though the effects aren’t very long-lasting, Gasquet says. “Sodium hyaluronate is best for people who have normal skin because it will allow moisture to seep in, but you don’t really need a heavy-duty, long-lasting effect.” This is the ingredient you’ll likely find in serums.
- Sodium acetylated hyaluronate has the benefits of sodium hyaluronate but with longer-lasting results. It’s best for people who need moisture, such as those with dry skin, those who live in dry climates, or those looking for a product for the dry winter months.
Does Hyaluronic Acid Have Any Side Effects?
Hyaluronic acid is generally safe for all skin types and doesn’t typically lead to any adverse reactions when applied topically, Marchbein says.
Marchbein points out that hyaluronic acid is also found in a large number of injectable fillers, and while the ingredient itself is safe, the procedure can be risky and should only be performed by a doctor certified by the American Board of Dermatology or the American Board of Plastic Surgery.
What to Look for in a Topical Hyaluronic Acid Product
Hyaluronic acid is a common ingredient in numerous skin care products, including:
- Serums
- Sheet masks
- Eye creams
- Moisturizers
- Cleansers
- Lip treatments
Before you purchase a topical product, follow these steps:
Check for Allergens and Vitamin C
Watch out for any ingredients you’re allergic to or that have caused you irritation in the past, says Gasquet.
Look for Its Molecular Weight
See if Alcohol Is Listed
Alcohol can counteract the ingredient’s moisturizing benefits.
“Isopropyl alcohol is very drying and can leave skin vulnerable to cracking, allowing skin break and possibly irritants and bacteria to enter where they don’t belong,” says Gasquet. “In addition, the ‘drying effect’ can cause the cells to become less plump, the complete reverse effect of what we want.”
She recommends looking at where alcohol appears on the ingredients list. Ingredients are listed in order of concentration, so if it’s one of the first six ingredients, the product may be drying, says Gasquet.
Avoid Fragrance
Don’t Shy Away From Water
Water is often the first ingredient in a hyaluronic acid product. It may seem like it’s diluting the product, but it actually helps make the hyaluronic acid more effective.
“Having a more water-based product rather than a cream, oil, or gel will allow the product to penetrate the skin more easily,” says Gasquet.
The Takeaway
- Hyaluronic acid is an active ingredient in a wide range of skin care products that’s responsible for delivering important hydration to the skin, as well as helping it retain its moisture.
- Hydration and moisture retention are the biggest benefits of hyaluronic acid in skin care, helping to protect a healthy skin barrier and giving the skin a plumper, brighter, and more youthful appearance.
- Since hyaluronic acid is a substance found naturally in the skin, adverse side effects to the ingredient in a skin care product are unlikely.
- When integrating hyaluronic acid into your skin care routine, look for water-based products that feature hyaluronic acid with a lower molecular weight and vitamin C, but skip added fragrances and alcohol.
Resources We Trust
- Cleveland Clinic: How to Tell if Your Skin Barrier Is Damaged and What to Do About It
- American Academy of Dermatology Association: Dermatologists’ Top Tips for Relieving Dry Skin
- Harvard Health Publishing: 9 Ways to Banish Dry Skin
- Associated Skin Care Professionals: Esthetician's Guide to Hyaluronic Acid
- National Institute on Aging: Infographic: Tips for Healthier Skin as You Age
- Lierova A et al. Hyaluronic Acid: Known for Almost a Century, but Still in Vogue. Pharmaceutics. April 11, 2022.
- Dicker KT et al. Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions. Acta Biomaterialia. December 18, 2013.
- Understanding Popular Skin Care Ingredients. Cleveland Clinic. August 2, 2022.
- Ghersetich I et al. Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology. February 1994.
- Kawada C et al. Ingested hyaluronan moisturizes dry skin. Nutrition Journal. July 11, 2014.
- How to Tell if Your Skin Barrier Is Damaged and What to Do About It. Cleveland Clinic. December 14, 2022.
- Aging changes in skin. MedlinePlus. July 15, 2024.
- Gao Y et al. Oral Administration of Hyaluronic Acid to Improve Skin Conditions via a Randomized Double‐Blind Clinical Test. Skin Research and Technology. November 20, 2023.
- Głaz P et al. Effect of Commonly Used Cosmetic Preservatives on Healthy Human Skin Cells. Cells. April 3, 2023.
- Juncan AM et al. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules. July 22, 2021.
- Contact Dermatitis. Cleveland Clinic. March 30, 2023.

Ross Radusky, MD
Medical Reviewer
Ross Radusky, MD, is a practicing board-certified dermatologist at the Dermatology Treatment and Research Center in Dallas. Originally from New York City, he graduated summa cum laude from the City University of New York and then received his MD from the New York University School of Medicine. There, he was inducted into the Alpha Omega Alpha Honor Medical Society and served as chapter president for two years. He completed his residency in dermatology at NewYork-Presbyterian Hospital and Weill Cornell Medical Center, and at Memorial Sloan Kettering Cancer Center.
Dr. Radusky practices general and cosmetic dermatology with a focus on the early detection of skin cancer, and provides patients with a personalized approach to looking their best at any age. He has authored articles and textbook chapters on the clues that our finger- and toenails may provide us about internal disease, as well as on comprehensive therapies for cosmetic dermatology and reversing the signs of skin aging.
Complementing his medical practice, Radusky has a strong passion for the cultural arts, particularly in expanding access to youths and seniors. He previously served as an artist instructor for the Rockaway Artists Alliance, a New York City nonprofit arts and education organization, and then served as both a board director and treasurer of the organization throughout his medical school training.
Radusky enjoys spending time outdoors with his wife Robyn, son Oliver, and poodle Lucy, where he can usually be found preventing photoaging and reducing the risk of skin cancer beneath an umbrella in a wide-brimmed hat. He is also the proud inventor of Sunshotz, the world’s only sunscreen measuring cup, designed to help patients of all ages apply the proper amount of sunscreen needed to enjoy all the sun without the burn.
