How Stress and Ulcerative Colitis Are Linked and 6 Ways to Cope

“Stress is well-known for exacerbating inflammatory bowel disease symptoms,” says Jordan Axelrad, MD, MPH, an associate professor of medicine at New York University’s Grossman School of Medicine and a gastroenterologist at NYU Langone Health’s Inflammatory Bowel Disease Center in New York City. “My patients always tell me that their symptoms feel worse when they’re stressed.”
Treatment for UC usually involves medications like aminosalicylates, corticosteroids, and immune-system suppressors to address inflammation. But finding ways to manage your stress levels could also relieve some of your discomfort if you have UC. Here are six tips that can help.
1. Try Yoga to Boost Your Quality of Life
You may find yoga classes at many local gyms and recreation centers or via online resources and apps.
2. Take Deep Breaths to Calm Your Gut
Breathing deeply can help reduce gut pain and cramping from ulcerative colitis, says Sarah Kinsinger, PhD, director of behavioral medicine for the digestive health program at Loyola University Health System in Oakbrook Terrace, Illinois.
“Deep breathing elicits a parasympathetic relaxation response that physiologically helps the body relax by increasing blood flow and oxygen to the gut,” Kinsinger says.
Experiment with different deep-breathing techniques, including diaphragmatic breathing and alternate nostril breathing, to learn what helps you relax.
3. Try Hypnotherapy
Hypnotherapy uses guided meditation, hypnosis, and concentration to achieve a heightened state of awareness. “Gut-directed hypnotherapy can influence gut secretions, reduce pain, and prolong remission in those with UC,” Kinsinger says.
4. Sleep Better to Recharge
Not only can a good night’s rest help you relax and reset, but it may also decrease your stress and lower your risk of a UC flare.
5. Exercise
That said, exercise may be uncomfortable for some people with UC. “However, I encourage them to push through because physical activity can improve fatigue and some disease activity,” Dr. Axelrad says.
6. Consider Cognitive Behaviorial Therapy
“It is important that [people with UC] meet with a psychologist at least once to address stress and [the] psychological impact of the disease,” says Lilani Perera, MD, a gastroenterologist and director of the Inflammatory Bowel Disease Center at Tufts Medical Center in Boston. “We strongly recommend integrated care, including CBT, to address psychological needs in IBD.”
The Takeaway
- Alongside standard treatments, lifestyle changes like managing stress may help reduce ulcerative colitis (UC) symptoms.
- Known stress-busting activities like yoga, deep breathing, or exercise may be helpful for you.
- Research suggests cognitive behavioral therapy, a type of talk therapy geared toward changing thinking and behavior patterns to better cope with stress, may help people with UC.
Resources We Trust
- Cleveland Clinic: Ulcerative Colitis and Your Mental Health
- Mayo Clinic: Ulcerative Colitis
- Crohn’s & Colitis Foundation: Stress and IBD: Breaking the Vicious Cycle
- Johns Hopkins Medicine: The Brain-Gut Connection
- Centers for Disease Control and Prevention: Inflammatory Bowel Disease (IBD)
- Sauk JS et al. High Perceived Stress Is Associated With Increased Risk of Ulcerative Colitis Clinical Flares. Clinical Gastroenterology and Hepatology. March 2023.
- Ge L et al. Psychological Stress in Inflammatory Bowel Disease: Psychoneuroimmunological Insights Into Bidirectional Gut–Brain Communications. Frontiers in Immunology. October 6, 2022.
- The Brain-Gut Connection. Johns Hopkins Medicine.
- Wilke E et al. Effects of Yoga in Inflammatory Bowel Diseases and on Frequent IBD-Associated Extraintestinal Symptoms Like Fatigue and Depression. Complementary Therapies in Clinical Practice. November 2021.
- Rozich JJ et al. Effect of Lifestyle Factors on Outcomes in Patients With Inflammatory Bowel Diseases. The American Journal of Gastroenterology. June 2020.
- Barnes A et al. A Systematic Review and Meta-Analysis of the Prevalence of Poor Sleep in Inflammatory Bowel Disease. SLEEP Advances. 2022.
- Sleep Tips: 6 Steps to Better Sleep. Mayo Clinic. January 31, 2025.
- Ulcerative Colitis Flare-Ups: 5 Tips to Manage Them. Mayo Clinic. March 25, 2025.
- Exercise. Crohn’s & Colitis Foundation.
- What Is Cognitive Behavioral Therapy? American Psychological Association. 2017.
- Chen J et al. The Physiological and Psychological Effects of Cognitive Behavior Therapy on Patients With Inflammatory Bowel Disease Before COVID-19: A Systematic Review. BMC Gastroenterology. December 15, 2021.

Yuying Luo, MD
Medical Reviewer
Yuying Luo, MD, is an assistant professor of medicine at Mount Sinai West and Morningside in New York City. She aims to deliver evidence-based, patient-centered, and holistic care for her patients.
Her clinical and research focus includes patients with disorders of gut-brain interaction such as irritable bowel syndrome and functional dyspepsia; patients with lower gastrointestinal motility (constipation) disorders and defecatory and anorectal disorders (such as dyssynergic defecation); and women’s gastrointestinal health.
She graduated from Harvard with a bachelor's degree in molecular and cellular biology and received her MD from the NYU Grossman School of Medicine. She completed her residency in internal medicine at the Icahn School of Medicine at Mount Sinai, where she was also chief resident. She completed her gastroenterology fellowship at Mount Sinai Hospital and was also chief fellow.

Dennis Thompson Jr
Author
Dennis Thompson is a career journalist with 30 years of experience, writing for newspapers in Virginia, West Virginia, Florida, Delaware, and Oregon. He is a senior reporter for HealthDay and covers health news from a consumer angle, taking the latest medical advances and explaining their importance in an approachable way. Thompson holds a bachelor of arts degree in communication studies from Virginia Tech and a master of arts degree in mass communication from the University of Florida. He is an avid cyclist, geek culture enthusiast, and avowed foodie.